Epigenetic Factors and Mitochondrial Biology in Yeast: A New Paradigm for the Study of Cancer Metabolism?

Epigenetic Factors and Mitochondrial Biology in Yeast: A New Paradigm for the Study of Cancer Metabolism?

Blog Article

Bidirectional cross-talk between nuclear and mitochondrial DNA is fundamental Cast for cell homeostasis.Epigenetic mechanisms regulate the inter-organelle communication between nucleus and mitochondria.Recent research highlights not only the retrograde activation of nuclear gene transcription in case of mitochondria dysfunction, but also the role of post-translational modifications of mitochondrial proteins in respiratory metabolism.Here we discuss some aspects and novel findings in Saccharomyces cerevisiae.In yeast, KAT-Gcn5 and DUB-Ubp8 have a role in respiration and are localized, as single proteins, into mitochondria.

These findings, HISENSE RQ689N4BD1 Fridge Freezer - Silver beside the canonical and widely known nuclear activity of SAGA complex in chromatin regulation, provide novel clues on promising aspects linking evolutionary conserved epigenetic factors to the re-programmed metabolism of cancer cells.